1.Weapon Unlocks
| Weapon | Requirement |
|---|
| Infinite Rocket Launcher | Complete Normal or Hard in under 3 hours |
| Samurai Edge (infinite) | Complete Normal or Hard in under 5 hours |
2.Mode Unlocks
| Mode | Requirement |
|---|
| Once Again.. | Complete the game once on any difficulty |
| Real Survivor | Complete the game on Normal |
| Invisible Enemy | Complete Real Survivor (all enemies become transparent) |
| One Dangerous Zombie | Complete with both Chris and Jill on Normal+ on the same save |
3.Costume Unlocks
| Costume | Requirement |
|---|
| Sarah Connor (Jill) | Clear once as Jill |
| Nemesis Outfit (Jill) | Clear twice as Jill |
| The Mexican (Chris) | Clear once as Chris |
| Code Veronica (Chris) | Clear twice as Chris |
4.Tips and Glitches
- Infinite Grenade ammo: Equip the Grenade Launcher with any rounds and take Flame Rounds from the Item Box. Open the box again, put the Flame Rounds back; on the box menu highlight Flame Rounds and press A — the cursor jumps to the Grenade Launcher slot. Press A again for 456 Flame Rounds. Repeat for other round types.
- Check if a zombie is dead: After shooting one down, look down — a pool of blood means it's dead; none means it's still alive. Or back up without getting too close; if alive, your character does a wary backup.
- Make a zombie dance: Shoot at a zombie's feet three times with the pistol, then aim straight up and fire once; done right it looks like it's dancing.
- Battle Mode: Save, then at the Title screen hold X Y Z Start on Controller 2; when you hear "Resident Evil", press Start on Controller 1 — Battle Mode unlocks.
- Special key / locked closet: The key for the locked closet in the large-mirror room is added to your save once you finish the game with both characters rescued.
5.Ending Bonuses (Once Again)
Complete the game as Jill or Chris and save; a new main-menu background appears. Selecting "Once Again" lets you choose a new difficulty and gives a key for a new costume (second-floor large-mirror room, closet at the back). Completing Once Again on Normal in under 5 hours unlocks Real Survivor mode, the infinite-ammo .40 S&W (replaces the knife) and manual aiming.
